Cancer

Microenvironmental disorders exhibited by malignant tumors

Abnormal features characterize the microenvironment of cancer cells:

1) a dense vascular network to supply nutrients required by tumor cells. This is the result of the generation of new capillaries (neoangiogenesis);

2) numerous immune cells: lymphocytes and Antigen Presenting Cells (APC: macrophages and dendritic cells);

3) abundant body fluid exudate as a result of inflammation.

These features are triggered by local factors released by cancer cells. These pathologic local factors are of various origins, some viral (such as HPV-16 E7, HTLV-1 Tax protein) and others cytokinic such as the Vascular Endothelial Growth Factor (VEGF).

NEOVACS' E7 toxoid immunogen targets deleterious effects of HPV-16 E7 viral toxin in cervix cancer by triggering specific neutralizing Abs. NEOVACS' VEGF kinoid immunogen targets neoangiogenesis in cancer by eliciting neutralizing Abs against VEGF.